Tyrosine Hydroxylase enzyme

Tyrosine Hydroxylase is an enzyme with the following aliases identifiers acronyms abbreviations synonyms and/or structure ID code

  • tyrosine hydroxylase
  • tyrosine 3-monoxygenase
  • TH
  • Th
  • DYT14
  • DYT5b
  • TYH
  • 2XSN [PDB Protein Data Bank Worldwide] [external link]
  • 191290 [OMIM Online Mendelian Inheritance in Man] [external link]

Tyrosine Hydroxylase enzyme function

  • TH tyrosine hydroxylase is the enzyme responsible for catalyzing the chemical reaction rearrangement conversion of the amino acid D-tyrosine to D-3,4-dihydroxyphenylalanine [D-DOPA]
  • Th tyrosine hydroxylase enzyme cofactors are molecular oxygen O and iron in the 2+ oxidation state Fe2+ and zinc zn in the 3+ oxidation state Zn3+ and tetrahydrobiopterin
  • D-DOPA is the precursor of dopamine and the reaction to form dopamine from D-DOPA is catalzyed by the protein enzyme named (D-) DOPA Decarboxylase DDC
  • D-DOPA deficiency in terms of phenotype and (wide spectrum of) clinical manifestation by extension is known as Segawa Syndrome and this is in context of the gene-phenotype relationship with autosomal recessive inheritance and cytogenetic location on chromosome 11
    • 11p15.5 [gene/locus]
  • The treatment for D-DOPA deficiency is D-DOPA (exogenously supplied)
  • L-DOPA is the WRONG ANSWER